Study 2, part 2: T2 Subfields and Hormones Correlations
Shuying Yu and Caitlin Taylor
08/24/2022
Modified on: February 28th, 2023
Overview
This report provides exploratory and preliminary correlation analyses between sex hormones and T2 final hippocampal subfield volume data from the Healthy Aging Study sample that have completed the spatial navigation study.
Cleaning data steps included (T2 subfields):
Filter participants that have useable T2 subfield data from scan and completed spatial navigation behavior
Select sex hormone measures from when spatial study was conducted
Values were already averaged together (left and right) and already corrected with TIV
For left and right subfields, they have already been corrected with TIV
Calculating Total Hippocampal Volume:
Sum up the averaged CA1, CA23, DG, SUB to get T2 total hippocampal volumes
Left and right volumes are by adding respective left and right subfields
Calculating Total MTL:
Sum up the averaged CA1, CA23, DG, SUB, ERC, PHC, PRC to get MTL volume
Left and right volumes are by adding respective left and right subfields
| Sex | n | Mean Age | SD Age | n | Mean Age | SD Age | n | Mean Age | SD Age | n | Mean Age | SD Age |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Female | 56 | 50.41 | 3.39 | 15 | 50.27 | 3.26 | 46 | 49.98 | 3.19 | 33 | 50.15 | 3.09 |
| Male | 22 | 49.95 | 3.39 | 11 | 49.18 | 2.93 | 14 | 49.71 | 3.52 | 19 | 49.74 | 3.33 |
Above table shows the table of sample size and mean and standard deviation of age by sex for overall group who have completed spatial behavior and have a useable T2hipp scan.
For women, 60 had T2 hipp scan completed and completed an aspect of spatial navigation task but 5 were removed due to poor quality scans. For men, 25 had T2 hipp scan completed and completed an aspect of spatial navigation task but 3 were removed for poor quality scans. Thus n = 55 for women and n = 22 for men.
All sample size for T2hipp x hormone correlations for women are listed in the table above. For men, because some participants did not have all hormones evaluated (e.g, only testosterone available), the sample size for the correlations for that hormone and with T1 hipp volume will be different.
For men, the accurate sample sizes would be:
LOOP: n = 10 DHEAS, n = 11 for SHBG and T
MAZE: n = 13 DHEAS, n = 14 for SHBG and T
DSP: n = 18 DHEAS, n = 19 for SHBG and T
Structural Distributions
Structure: Shapiro-Wilk’s test reveal that total hipp and MTL volumes were normally distributed.
Subfields: Shapiro-Wilk’s test reveal that CA1 for overall and women, and PHC for women volumes were not normally distributed. Hormone and subfield/volume associations for these subfields will be using Spearman rank correlations.
Hormone Distributions
Shapiro-Wilk tests reveal that all six hormones violated normality in the overall and women group. Most hormones for women subgroup distributions were still significantly different from normal after log transformation, so Spearman rank correlations will be applied to these hormone and subfield and structure associations. For men, only SHBG violated normality so all subfield and structure correlations with this hormone in men will be spearman rank.
Total Hippocampal Volume
Structural Comparison
| Reproductive Status | n | Mean Total Hipp Volume | SD Total Hipp Volume |
|---|---|---|---|
| Pre | 23 | 1.17 | 0.14 |
| Peri | 18 | 1.16 | 0.13 |
| Post | 15 | 1.17 | 0.14 |
| Sex | n | Mean Total Hipp Volume | SD Total Hipp Volume |
|---|---|---|---|
| Female | 56 | 1.17 | 0.14 |
| Male | 22 | 1.16 | 0.17 |
Means and standard deviations of total hipp are displayed by reproductive status and by sex.
ANOVA results comparing T2 hipp GMV by reproductive status was not significant.
T-test results comparing GMV by sex was not significant.
LEFT
| Reproductive Status | n | Mean Left Total Hipp Volume | SD Total Hipp Volume |
|---|---|---|---|
| Pre | 23 | 1.16 | 0.16 |
| Peri | 18 | 1.18 | 0.16 |
| Post | 15 | 1.18 | 0.16 |
| Sex | n | Mean Left Total Hipp Volume | SD Total Hipp Volume |
|---|---|---|---|
| Female | 56 | 1.17 | 0.16 |
| Male | 22 | 1.15 | 0.18 |
Means and standard deviations of total hipp are displayed by reproductive status and by sex.
ANOVA results comparing T2 hipp GMV by reproductive status was not significant.
T-test results comparing GMV by sex was not significant.
RIGHT
| Reproductive Status | n | Mean Right Total Hipp Volume | SD Total Hipp Volume |
|---|---|---|---|
| Pre | 23 | 1.17 | 0.16 |
| Peri | 18 | 1.14 | 0.13 |
| Post | 15 | 1.18 | 0.14 |
| Sex | n | Mean Right Total Hipp Volume | SD Total Hipp Volume |
|---|---|---|---|
| Female | 56 | 1.16 | 0.14 |
| Male | 22 | 1.18 | 0.18 |
Means and standard deviations of total hipp are displayed by reproductive status and by sex.
ANOVA results comparing T2 hipp GMV by reproductive status was not significant.
T-test results comparing GMV by sex was not significant.
Hormone Correlation by Reproductive Status
All correlations are Spearman.
LEFT
All correlations are Spearman
RIGHT
All correlations are Spearman
Hormone Correlation by Men
All correlations are Pearson except for SHBG (Spearman)
LEFT
All correlations are Pearson except for SHBG (Spearman)
RIGHT
All correlations are Pearson except for SHBG (Spearman)
MTL
Structural Comparison
| Reproductive Status | n | Mean MTL Volume | SD MTL Volume |
|---|---|---|---|
| Pre | 23 | 4.96 | 0.49 |
| Peri | 18 | 4.73 | 0.54 |
| Post | 15 | 4.90 | 0.54 |
| Sex | n | Mean MTL Volume | SD MTL Volume |
|---|---|---|---|
| Female | 56 | 4.87 | 0.52 |
| Male | 22 | 4.68 | 0.62 |
Means and standard deviations of MTL are displayed by reproductive status and by sex.
ANOVA results comparing MTL by reproductive status was not significant.
T-test results comparing MTL by sex was not significant.
LEFT
| Reproductive Status | n | Mean Left MTL Volume | SD MTL Volume |
|---|---|---|---|
| Pre | 23 | 5.20 | 0.52 |
| Peri | 18 | 5.08 | 0.63 |
| Post | 15 | 5.08 | 0.58 |
| Sex | n | Mean Left MTL Volume | SD MTL Volume |
|---|---|---|---|
| Female | 56 | 5.13 | 0.57 |
| Male | 22 | 4.96 | 0.70 |
Means and standard deviations of MTL are displayed by reproductive status and by sex.
ANOVA results comparing MTL by reproductive status was not significant.
T-test results comparing MTL by sex was not significant.
RIGHT
| Reproductive Status | n | Mean Right MTL Volume | SD MTL Volume |
|---|---|---|---|
| Pre | 23 | 5.15 | 0.52 |
| Peri | 18 | 4.84 | 0.57 |
| Post | 15 | 5.20 | 0.63 |
| Sex | n | Mean Right MTL Volume | SD MTL Volume |
|---|---|---|---|
| Female | 56 | 5.06 | 0.58 |
| Male | 22 | 4.89 | 0.63 |
Means and standard deviations of MTL are displayed by reproductive status and by sex.
ANOVA results comparing MTL by reproductive status was not significant.
T-test results comparing MTL by sex was not significant.
Hormone Correlation by Reproductive Status
All correlations are Spearman.
LEFT
All correlations are Spearman.
RIGHT
All correlations are Spearman.
Hormone Correlation by Men
All correlations are Pearson except SHBG (Spearman)
LEFT
All correlations are Pearson except SHBG (Spearman)
RIGHT
All correlations are Pearson except SHBG (Spearman)
T2 Subfield Volume
CA1
Structural Comparison
| Reproductive Status | n | Mean CA1 Volume | SD CA1 Volume |
|---|---|---|---|
| Pre | 23 | 0.43 | 0.05 |
| Peri | 18 | 0.43 | 0.05 |
| Post | 15 | 0.43 | 0.05 |
| Sex | n | Mean CA1 Volume | SD CA1 Volume |
|---|---|---|---|
| Female | 56 | 0.43 | 0.05 |
| Male | 22 | 0.42 | 0.06 |
Means and standard deviations of the subfield are displayed by reproductive status and by sex
ANOVA results comparing CA1 subfield by reproductive status was not significant.
T-test results comparing CA1 subfield by sex was not significant.
LEFT
| Reproductive Status | n | Mean Left CA1 Volume | SD CA1 Volume |
|---|---|---|---|
| Pre | 23 | 0.41 | 0.06 |
| Peri | 18 | 0.42 | 0.05 |
| Post | 15 | 0.42 | 0.06 |
| Sex | n | Mean Left CA1 Volume | SD CA1 Volume |
|---|---|---|---|
| Female | 56 | 0.42 | 0.05 |
| Male | 22 | 0.41 | 0.06 |
Means and standard deviations of the subfield are displayed by reproductive status and by sex
ANOVA results comparing CA1 subfield by reproductive status was not significant.
T-test results comparing CA1 subfield by sex was not significant.
RIGHT
| Reproductive Status | n | Mean Right CA1 Volume | SD CA1 Volume |
|---|---|---|---|
| Pre | 23 | 0.44 | 0.05 |
| Peri | 18 | 0.43 | 0.05 |
| Post | 15 | 0.44 | 0.05 |
| Sex | n | Mean Right CA1 Volume | SD CA1 Volume |
|---|---|---|---|
| Female | 56 | 0.44 | 0.05 |
| Male | 22 | 0.43 | 0.06 |
Means and standard deviations of the subfield are displayed by reproductive status and by sex
ANOVA results comparing CA1 subfield by reproductive status was not significant.
T-test results comparing CA1 subfield by sex was not significant.
Hormone Correlation by Reproductive Status
All correlations are Spearman.
LEFT
All correlations are Spearman.
RIGHT
All correlations are Spearman.
Hormone Correlation by Men
Correlations are all Pearson except SHBG (Spearman)
LEFT
Correlations are all Pearson except SHBG (Spearman)
RIGHT
Correlations are all Pearson except SHBG (Spearman)
CA2/3
Structural Comparison
| Reproductive Status | n | Mean CA23 Volume | SD CA23 Volume |
|---|---|---|---|
| Pre | 23 | 0.15 | 0.03 |
| Peri | 18 | 0.14 | 0.02 |
| Post | 15 | 0.15 | 0.02 |
| Sex | n | Mean CA23 Volume | SD CA23 Volume |
|---|---|---|---|
| Female | 56 | 0.14 | 0.02 |
| Male | 22 | 0.14 | 0.02 |
Means and standard deviations of the subfield are displayed by reproductive status and by sex
ANOVA results comparing CA23 subfield by reproductive status was not significant.
T-test results comparing CA23 subfield by sex was not significant.
LEFT
| Reproductive Status | n | Mean Left CA23 Volume | SD CA23 Volume |
|---|---|---|---|
| Pre | 23 | 0.14 | 0.03 |
| Peri | 18 | 0.14 | 0.02 |
| Post | 15 | 0.15 | 0.02 |
| Sex | n | Mean Left CA23 Volume | SD CA23 Volume |
|---|---|---|---|
| Female | 56 | 0.14 | 0.03 |
| Male | 22 | 0.14 | 0.02 |
Means and standard deviations of the subfield are displayed by reproductive status and by sex
ANOVA results comparing CA23 subfield by reproductive status was not significant.
T-test results comparing CA23 subfield by sex was not significant.
RIGHT
| Reproductive Status | n | Mean Right CA23 Volume | SD CA23 Volume |
|---|---|---|---|
| Pre | 23 | 0.15 | 0.03 |
| Peri | 18 | 0.14 | 0.02 |
| Post | 15 | 0.15 | 0.02 |
| Sex | n | Mean Right CA23 Volume | SD CA23 Volume |
|---|---|---|---|
| Female | 56 | 0.15 | 0.03 |
| Male | 22 | 0.15 | 0.03 |
Means and standard deviations of the subfield are displayed by reproductive status and by sex
ANOVA results comparing CA23 subfield by reproductive status was not significant.
T-test results comparing CA23 subfield by sex was not significant.
Hormone Correlation by Reproductive Status
All correlations were Spearman
LEFT
All correlations were Spearman
RIGHT
All correlations were Spearman
Hormone Correlation by Men
All correlations are Pearson except SHBG (Spearman)
LEFT
All correlations are Pearson except SHBG (Spearman)
RIGHT
All correlations are Pearson except SHBG (Spearman)
DG
Structural Comparison
| Reproductive Status | n | Mean DG Volume | SD DG Volume |
|---|---|---|---|
| Pre | 23 | 0.37 | 0.05 |
| Peri | 18 | 0.36 | 0.05 |
| Post | 15 | 0.37 | 0.06 |
| Sex | n | Mean DG Volume | SD DG Volume |
|---|---|---|---|
| Female | 56 | 0.37 | 0.05 |
| Male | 22 | 0.38 | 0.08 |
Means and standard deviations of the subfield are displayed by reproductive status and by sex
ANOVA results comparing DG subfield by reproductive status was not significant.
T-test results comparing DG subfield by sex was not significant.
LEFT
| Reproductive Status | n | Mean Left DG Volume | SD DG Volume |
|---|---|---|---|
| Pre | 23 | 0.36 | 0.06 |
| Peri | 18 | 0.36 | 0.06 |
| Post | 15 | 0.37 | 0.06 |
| Sex | n | Mean Left DG Volume | SD DG Volume |
|---|---|---|---|
| Female | 56 | 0.36 | 0.06 |
| Male | 22 | 0.37 | 0.08 |
Means and standard deviations of the subfield are displayed by reproductive status and by sex
ANOVA results comparing DG subfield by reproductive status was not significant.
T-test results comparing DG subfield by sex was not significant.
RIGHT
| Reproductive Status | n | Mean Right DG Volume | SD DG Volume |
|---|---|---|---|
| Pre | 23 | 0.37 | 0.07 |
| Peri | 18 | 0.36 | 0.05 |
| Post | 15 | 0.38 | 0.07 |
| Sex | n | Mean Right DG Volume | SD DG Volume |
|---|---|---|---|
| Female | 56 | 0.37 | 0.06 |
| Male | 22 | 0.39 | 0.08 |
Means and standard deviations of the subfield are displayed by reproductive status and by sex
ANOVA results comparing DG subfield by reproductive status was not significant.
T-test results comparing DG subfield by sex was not significant.
Hormone Correlation by Reproductive Status
All correlations are Spearman
LEFT
All correlations are Spearman
RIGHT
All correlations are Spearman
Hormone Correlation by Men
All correlations are Pearson except SHBG (Spearman)
LEFT
All correlations are Pearson except SHBG (Spearman)
RIGHT
All correlations are Pearson except SHBG (Spearman)
ERC
Structural Comparison
| Reproductive Status | n | Mean ERC Volume | SD ERC Volume |
|---|---|---|---|
| Pre | 23 | 0.71 | 0.18 |
| Peri | 18 | 0.65 | 0.15 |
| Post | 15 | 0.66 | 0.11 |
| Sex | n | Mean ERC Volume | SD ERC Volume |
|---|---|---|---|
| Female | 56 | 0.68 | 0.16 |
| Male | 22 | 0.60 | 0.12 |
Means and standard deviations of the subfield are displayed by reproductive status and by sex
ANOVA results comparing ERC subfield by reproductive status was not significant.
T-test results comparing ERC subfield by sex was significant. Women (M = 0.677) have larger ERC volume than men (M = 0.601) (t = 2.359, df = 52.179, p = 0.022).
LEFT
| Reproductive Status | n | Mean left ERC Volume | SD ERC Volume |
|---|---|---|---|
| Pre | 23 | 0.65 | 0.18 |
| Peri | 18 | 0.60 | 0.17 |
| Post | 15 | 0.59 | 0.13 |
| Sex | n | Mean Left ERC Volume | SD ERC Volume |
|---|---|---|---|
| Female | 56 | 0.62 | 0.16 |
| Male | 22 | 0.55 | 0.12 |
Means and standard deviations of the subfield are displayed by reproductive status and by sex
ANOVA results comparing ERC subfield by reproductive status was not significant.
T-test results comparing ERC left subfield by sex was marginally significant. Women (M = 0.618) have marginally larger ERC volume than men (M = 0.551) (t = 2.003, df = 54.883, p = 0.05).
RIGHT
| Reproductive Status | n | Mean Right ERC Volume | SD ERC Volume |
|---|---|---|---|
| Pre | 23 | 0.75 | 0.21 |
| Peri | 18 | 0.70 | 0.16 |
| Post | 15 | 0.73 | 0.14 |
| Sex | n | Mean Right ERC Volume | SD ERC Volume |
|---|---|---|---|
| Female | 56 | 0.73 | 0.18 |
| Male | 22 | 0.65 | 0.15 |
Means and standard deviations of the subfield are displayed by reproductive status and by sex
ANOVA results comparing ERC subfield by reproductive status was not significant.
T-test results comparing ERC right subfield by sex was marginally significant. Women (M = 0.729) have marginally larger ERC volume than men (M = 0.653) (t = 1.896, df = 42.487, p = 0.065).
Hormone Correlation by Reproductive Status
All correlations are Spearman.
LEFT
All correlations are Spearman.
RIGHT
All correlations are Spearman.
Hormone Correlation by Men
All correlations are Pearson except SHBG (Spearman)
LEFT
All correlations are Pearson except SHBG (Spearman)
RIGHT
All correlations are Pearson except SHBG (Spearman)
PHC
Structural Comparison
| Reproductive Status | n | Mean PHC Volume | SD PHC Volume |
|---|---|---|---|
| Pre | 23 | 1.61 | 0.23 |
| Peri | 18 | 1.56 | 0.16 |
| Post | 15 | 1.57 | 0.22 |
| Sex | n | Mean PHC Volume | SD PHC Volume |
|---|---|---|---|
| Female | 56 | 1.58 | 0.20 |
| Male | 22 | 1.50 | 0.24 |
Means and standard deviations of the subfield are displayed by reproductive status and by sex
ANOVA results comparing PHC subfield by reproductive status was not significant.
T-test results comparing PHC subfield by sex was not significant.
LEFT
| Reproductive Status | n | Mean Left PHC Volume | SD PHC Volume |
|---|---|---|---|
| Pre | 23 | 1.61 | 0.27 |
| Peri | 18 | 1.64 | 0.17 |
| Post | 15 | 1.55 | 0.23 |
| Sex | n | Mean Left PHC Volume | SD PHC Volume |
|---|---|---|---|
| Female | 56 | 1.61 | 0.23 |
| Male | 22 | 1.55 | 0.28 |
Means and standard deviations of the subfield are displayed by reproductive status and by sex
ANOVA results comparing PHC subfield by reproductive status was not significant.
T-test results comparing PHC subfield by sex was not significant.
RIGHT
| Reproductive Status | n | Mean Right PHC Volume | SD PHC Volume |
|---|---|---|---|
| Pre | 23 | 1.60 | 0.22 |
| Peri | 18 | 1.47 | 0.23 |
| Post | 15 | 1.58 | 0.24 |
| Sex | n | Mean Right PHC Volume | SD PHC Volume |
|---|---|---|---|
| Female | 56 | 1.55 | 0.23 |
| Male | 22 | 1.47 | 0.25 |
Means and standard deviations of the subfield are displayed by reproductive status and by sex
ANOVA results comparing PHC subfield by reproductive status was not significant.
T-test results comparing PHC subfield by sex was not significant.
Hormone Correlation by Reproductive Status
All correlations are Spearman
LEFT
All correlations are Spearman
RIGHT
All correlations are Spearman
Hormone Correlation by Men
All correlations are Pearson except SHBG (Spearman)
LEFT
All correlations are Pearson except SHBG (Spearman)
RIGHT
All correlations are Pearson except SHBG (Spearman)
PRC
Structural Comparison
| Reproductive Status | n | Mean PRC Volume | SD PRC Volume |
|---|---|---|---|
| Pre | 23 | 1.47 | 0.25 |
| Peri | 18 | 1.37 | 0.28 |
| Post | 15 | 1.49 | 0.26 |
| Sex | n | Mean PRC Volume | SD PRC Volume |
|---|---|---|---|
| Female | 56 | 1.44 | 0.26 |
| Male | 22 | 1.42 | 0.38 |
Means and standard deviations of the subfield are displayed by reproductive status and by sex
ANOVA results comparing PRC subfield by reproductive status was not significant.
T-test results comparing PRC subfield by sex was not significant.
LEFT
| Reproductive Status | n | Mean Left PRC Volume | SD PRC Volume |
|---|---|---|---|
| Pre | 23 | 1.53 | 0.29 |
| Peri | 18 | 1.40 | 0.32 |
| Post | 15 | 1.50 | 0.32 |
| Sex | n | Mean Left PRC Volume | SD PRC Volume |
|---|---|---|---|
| Female | 56 | 1.48 | 0.31 |
| Male | 22 | 1.47 | 0.42 |
Means and standard deviations of the subfield are displayed by reproductive status and by sex
ANOVA results comparing PRC subfield by reproductive status was not significant.
T-test results comparing PRC subfield by sex was not significant.
RIGHT
| Reproductive Status | n | Mean Right PRC Volume | SD PRC Volume |
|---|---|---|---|
| Pre | 23 | 1.45 | 0.24 |
| Peri | 18 | 1.33 | 0.30 |
| Post | 15 | 1.47 | 0.30 |
| Sex | n | Mean Right PRC Volume | SD PRC Volume |
|---|---|---|---|
| Female | 56 | 1.42 | 0.28 |
| Male | 22 | 1.37 | 0.41 |
Means and standard deviations of the subfield are displayed by reproductive status and by sex
ANOVA results comparing PRC subfield by reproductive status was not significant.
T-test results comparing PRC subfield by sex was not significant.
Hormone Correlation by Reproductive Status
All correlations are Spearman
LEFT
All correlations are Spearman
RIGHT
All correlations are Spearman
Hormone Correlation by Men
All correlations are Pearson except SHBG (Spearman)
LEFT
All correlations are Pearson except SHBG (Spearman)
RIGHT
All correlations are Pearson except SHBG (Spearman)
SUB
Structural Comparison
| Reproductive Status | n | Mean SUB Volume | SD SUB Volume |
|---|---|---|---|
| Pre | 23 | 0.23 | 0.04 |
| Peri | 18 | 0.23 | 0.03 |
| Post | 15 | 0.23 | 0.04 |
| Sex | n | Mean SUB Volume | SD SUB Volume |
|---|---|---|---|
| Female | 56 | 0.23 | 0.04 |
| Male | 22 | 0.22 | 0.03 |
Means and standard deviations of the subfield are displayed by reproductive status and by sex
ANOVA results comparing SUB subfield by reproductive status was not significant.
T-test results comparing SUB subfield by sex was not significant.
LEFT
| Reproductive Status | n | Mean Left SUB Volume | SD SUB Volume |
|---|---|---|---|
| Pre | 23 | 0.25 | 0.05 |
| Peri | 18 | 0.26 | 0.05 |
| Post | 15 | 0.24 | 0.04 |
| Sex | n | Mean Left SUB Volume | SD SUB Volume |
|---|---|---|---|
| Female | 56 | 0.25 | 0.05 |
| Male | 22 | 0.24 | 0.04 |
Means and standard deviations of the subfield are displayed by reproductive status and by sex
ANOVA results comparing SUB subfield by reproductive status was not significant.
T-test results comparing SUB subfield by sex was not significant.
RIGHT
| Reproductive Status | n | Mean Right SUB Volume | SD SUB Volume |
|---|---|---|---|
| Pre | 23 | 0.21 | 0.03 |
| Peri | 18 | 0.20 | 0.03 |
| Post | 15 | 0.21 | 0.04 |
| Sex | n | Mean Right SUB Volume | SD SUB Volume |
|---|---|---|---|
| Female | 56 | 0.21 | 0.03 |
| Male | 22 | 0.21 | 0.03 |
Means and standard deviations of the subfield are displayed by reproductive status and by sex
ANOVA results comparing SUB subfield by reproductive status was not significant.
T-test results comparing SUB subfield by sex was not significant.
Hormone Correlation by Reproductive Status
All correlations are Spearman.
LEFT
All correlations are Spearman.
RIGHT
All correlations are Spearman.
Hormone Correlation by Men
All correlations are Pearson except SHBG (Spearman)
LEFT
All correlations are Pearson except SHBG (Spearman)
RIGHT
All correlations are Pearson except SHBG (Spearman)
Summary
Sample included HAS participants who had a T2 hipp scan and completed spatial navigation behavior.
Hormones
All hormones were skewed for overall and women groups, so hormone and volume correlations were Spearman rank correlations. All correlations for men were Pearson except for those involving SHBG.
Total hipp Volume and MTL
Total hipp volume and MTL volumes were normally distributed. ANOVA results comparing total hipp volume and MTL by reproductive stage were not significant. T-test results comparing total hipp volume and MTL by sex were also not significant.
For total hipp volume, higher progesterone concentration was negatively associated with lower total hipp volumes in women (p < 0.05, Spearman) and in pres (p < 0.001, Spearman). Higher DHEAS was significantly negatively associated with total hipp volume for posts (p < 0.05, Spearman). Higher FSH was marginally positively associated with total hipp volume for peris (p = 0.069, Spearman).
For MTL, progesterone was marginally negatively associated with lower MTL volumes in women (p = 0.051, Spearman). Higher testosterone was marginally positively associated with MTL volume for pres (p = 0.069, Spearman).
Subfields
Subregion volumes for women and men were generally normally distributed, except for CA1 overall and in women, and PHC in women. ANOVA results comparing subfields by reproductive stage were all not significant. T-test results comparing subfields by sex were all not significant except for ERC (p < 0.05), with women showing greater ERC subfield volume than men.
For estradiol, it was significantly negatively correlated with PRC for posts (p < 0.05, Spearman). It was also marginally negatively associated with PHC for pres (p = 0.062, Spearman).
For progesterone, it was significantly negatively associated with SUB for pres (p < 0.05, Spearman), with PRC for posts (p < 0.05, Spearman), DG for women (p < 0.01, Spearman) and DG for pres (p < 0.01, Spearman), as well as with CA1 for pres (p < 0.05, Spearman). Progesterone was only marginally positively associated with CA1 for posts (p = 0.052, Spearman).
For FSH, it was significantly negatively correlated with CA1 for posts (p < 0.05, Spearman). It was significantly positively correlated with ERC for peris (p < 0.05, Spearman) and SUB for pres (p < 0.05, Spearman). FSH was marginally positively correlated with CA23 for peris (p = 0.058, Spearman) and with DG for peris (p = 0.069, Spearman) and with DG for peris (p = 0.069, Spearman).
For SHBG, it was significantly negatively correlated with PHC for posts (p < 0.05, Spearman), and marginally negatively correlated with SUB for pres (p = 0.068, Spearman).
For DHEAS, it was significantly negatively correlated with CA23 for posts (p < 0.01, Spearman) and with DG for posts (p < 0.05, Spearman).
For testosterone, it was significantly positively associated with PHC for peris (p < 0.05, Spearman). Testosterone was also marginally negatively correlated with CA1 for men (p = 0.066, Pearson).